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目的：研究维拉帕米、利舍平在淋球菌多重耐药性中的作用。方法：利用淋球菌快速定量药敏测试法对３０株淋球菌进行药物敏感性检测。所测菌株包括ＷＨＯ标准株，Ａ，Ｂ，Ｃ，Ｄ，Ｅ株及临床分离株，６种抗生素分别加利舍平、维拉帕米，测定两者对淋球菌耐药性的影响。结果：一定浓度利舍平降低药物对淋球菌的最小抑菌浓度最多可达８６％，而维拉帕米降低药物对淋球菌的最小抑菌浓度最多也可达８１％。结论：利舍平和维拉帕米对淋球菌的多重耐药性具有一定的逆转作用，可降低抗生素对淋球菌最小抑菌浓度
Objective: To investigate the role of verapamil and reserpine in the multi-drug resistance of Neisseria gonorrhoeae. Methods: Thirty Neisseria gonorrhoeae were tested for drug susceptibility using Neisseria gonorrhoeae rapid quantitative drug sensitivity test. The strains tested included WHO standard strains, strains A, B, C, D and E as well as clinical isolates. Six antibiotics, including galeamide and verapamil, were respectively tested for their resistance to gonococci. Results: The minimum inhibitory concentration (MIC) of reserpine to a certain concentration of Neisseria gonorrhoeae was up to 86%, while the minimum inhibitory concentration of verapamil to Neisseria gonorrhoeae was up to 81%. Conclusion: The results showed that both reserpine and verapamil reversed the multi-drug resistance of Neisseria gonorrhoeae and could reduce the minimum inhibitory concentration of antibiotics on Neisseria gonorrhoeae