论文部分内容阅读
蒿甲醚是青蒿素的衍生物之一,抗疟作用比青蒿素更强,为了进一步开展药物代谢及其动力学研究,我们合成了氘代β体蒿甲醚。标记部位在十二位碳和甲氧基碳上,共四个氘。合成路线如下:
Artemether is one of the derivatives of artemisinin and the anti-malaria effect is stronger than that of artemisinin. In order to further study drug metabolism and its kinetics, we have synthesized the deuterated β-body artemether. Marked on the twelve carbon and methoxy carbon, a total of four deuterium. The synthetic route is as follows: