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本文述评了4种抗抑郁新药的副作用及其临床重要性,并估价了这些药物在抑郁症现代治疗中的地位。阿莫沙平 阿莫沙平(amoxapine,AF)系二苯佐西平(dibenzoxazepine)三环抗抑郁药,具有起效快和副作用小的特点。其副作用为阻断突触后膜多巴胺受体,过量可导致毒性反应。1.多巴胺阻断的副作用动物试验表明,AP有抗抑郁(由于阻断去甲肾上腺素重吸收)和抗精神病(由于阻断突触后膜的多巴胺受体)作用。但临床研究表明,A P仅有
This article reviews the side effects and their clinical significance of four new antidepressants and assesses the status of these drugs in the modern treatment of depression. Amoxapine (amoxapine, AF) is a dibenzoxazepine tricyclic antidepressant with fast onset and low side effects. Side effects of its block postsynaptic dopamine receptors, excessive can lead to toxic reactions. Side Effects of Dopamine Blockade Animal studies have shown that AP has antidepressant (due to block norepinephrine reabsorption) and antipsychotic (due to the blockade of postsynaptic membrane dopamine receptors). However, clinical studies have shown that A P only