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控制感染发展和支持疗法,是治疗破伤风的原則。前者目前已非难題,而如何及时制止反射性肌痙攣的发作,以保証支持疗法的順利进行,則是治疗破伤风成敗的关鍵。破伤风外毒素一旦与中枢神經系統的細胞結合,即不易为特异性抗毒素中和,致使多突触反射弧調节失衡,兴奋亢进,临床上表現为伸、屈肌的同时反射性痙挚发作。文獻报道,氯丙嗪具有抑制神經細胞联合神經原、下视丘及网状結构系統的作用。应用氯丙嗪能控制患儿痙攣,而无抑制呼吸的副作用。我院于1963年11月至1964年3月間,采用大剂量氯丙嗪口服疗法,治疗新生儿破伤风12例,9例治愈,3例死亡。
Controlling the development of infections and supporting therapies is the principle of treating tetanus. The former is now no problem, and how to stop the onset of reflex muscle spasm in order to ensure the smooth progress of supportive therapy is the key to the success or failure of tetanus. Tetanus toxins and once the central nervous system cells, that is not easy for the specific antitoxin neutralization, resulting in imbalance of multi-synaptic reflex arc regulation, excitement hyperthyroidism, clinical manifestations of extensor, flexor reflex spasm attack . Reported in the literature, chlorpromazine inhibits nerve cells combined neurons, hypophyseal and reticular structure of the system. Application of chlorpromazine can control children with spasms, without inhibiting the side effects of breathing. Our hospital from November 1963 to March 1964, using high-dose oral chlorpromazine treatment of neonatal tetanus in 12 cases, 9 cases were cured and 3 died.