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目的:探讨中医药治疗脑出血最佳疗效出血量的界定。方法:72只wistar大鼠随机分为3组,假手术组、模型组和治疗组,模型组和治疗组又各分为4个小组,每组8只大鼠。造模后,假手术组和模型组给予安慰剂,治疗组给予中药治疗。给药3天后腹主动脉取血采用夹心酶联免疫法测定血清NSE浓度。结果:中药治疗组血清NSE水平明显低于模型组(P<0.05),特别是小量出血组(27μL、40μL)NSE水平明显低于大量出血组(53μL、67μL)(P<0.05)。结论:①中药对脑出血后血清NSE水平的调控有明显效果,可以保护脑组织的损伤,对小量脑出血作用更加明显。②NSE是反映脑出血后脑损伤程度的敏感指标。③提示NSE是否存在一个在机体发生实质性损伤时的临界点。
Objective: To explore the definition of the best therapeutic effect of intracerebral hemorrhage in Chinese medicine. Methods: 72 Wistar rats were randomly divided into 3 groups: sham operation group, model group and treatment group. The model group and treatment group were divided into 4 groups with 8 rats in each group. After modeling, placebo was administered to the sham group and model group, and traditional Chinese medicine was administered to the treatment group. Blood samples were taken from the abdominal aorta 3 days after administration and serum NSE concentrations were measured by sandwich enzyme-linked immunosorbent assay. Results: The serum NSE level in the traditional Chinese medicine treatment group was significantly lower than that in the model group (P<0.05), especially in the small amount of hemorrhage group (27μL, 40μL) NSE levels were significantly lower than the massive bleeding group (53μL, 67μL) (P<0.05). Conclusion: 1 Chinese medicine has a significant effect on the regulation of serum NSE levels after cerebral hemorrhage. It can protect the brain tissue from damage and has a more pronounced effect on small amounts of cerebral hemorrhage. 2NSE is a sensitive index that reflects the degree of brain injury after cerebral hemorrhage. 3 It indicates whether the NSE has a critical point when substantial damage occurs in the body.