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本文用硫代巴比妥酸法测定了25例原发性肾病综合征患儿血清丙二醛(MDA),结果:(1)肾病期单纯性肾病和肾炎性肾病血MDA分别为7.85±1.81nmol/ml、7.44±2.29nmol/ml,明显高于对照组(5.02±0.8nmol/ml),缓解期分别降至5.58±1.92nmol/ml和6.13±2.26nmol/ml;(2)血MDA与血总蛋白、白蛋白呈负相关,与24小时尿蛋白呈正相关,与血清胆固醇无线性关系;(3)激素耐药及激素依赖者血MDA明显升高。结果提示脂质过氧化反应在肾脏损伤中可能发挥重要作用,激素等治疗机制之一可能系抗氧化作用。
Thiobarbituric acid method was used to determine the serum malondialdehyde (MDA) in 25 children with primary nephrotic syndrome. Results: (1) The serum MDA in nephropathy patients with nephropathy and nephritis was 7.85 ± 1.81 ml and 7.44 ± 2.29nmol / ml, respectively, which were significantly lower than those in the control group (5.02 ± 0.8nmol / ml) and 5.58 ± 1.92nmol / ml and 6.13 ± 2.26nmol / ml respectively Blood total protein, albumin was negatively correlated with 24-hour urine protein was positively correlated with serum cholesterol and no linear relationship; (3) hormone resistance and hormone-dependent blood MDA was significantly higher. The results suggest that lipid peroxidation may play an important role in renal injury, and one of the therapeutic mechanisms such as hormone may be anti-oxidation.