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质子泵抑制剂是一类较新的抗溃疡药物。其代表药奥美拉唑（Omeprazole简称OME）商品名治赛克（Losec）是一个碱性化合物，Pka为3.97，胃酸可使之灭活，因此必须服用具有肠溶衣的制剂。口服后在十二指肠吸收，从血浆中迅速消除，但选择性地浓缩在胃壁细胞的酸性环境中。在壁细胞
Proton pump inhibitors are a new class of anti-ulcer drugs. Its representative drug, Omeprazole (OME), trade name Losec is a basic compound with a Pka of 3.97 which is inactivated by gastric acid and must therefore be administered in an enteric-coated form. After oral absorption in the duodenum, rapidly eliminated from the plasma, but selectively concentrated in the acidic gastric parietal cells. In the parietal cells