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氨苯哌酮(AG)是一种类固醇抑制剂。本文用AG治疗21例(女18,男3)皮质醇增多症患者,平均年龄35(24～60)岁,全部患者均有典型的临床征象及高皮质醇血症的实验依据。AG 用量每日0.5～0.75 g,疗程平均3(1～14)个月。用药1周血浆皮质醇、尿17—羟皮质类固醇及17—酮类固醇排量减少,3个月后有明显减少(与服药前比P<0.001)。结果:显效11例,有效7例,无效3例。AG 对皮质醇增多症的长期治疗,无疑是减轻临床症状的有效措施。
Castepirone (AG) is a steroid inhibitor. This article used AG to treat 21 patients (18 women, 3 men) with cortisol increase, with an average age of 35 (24-60) years. All patients had typical clinical signs and experimental evidence of hypercortisolemia. AG dosage is 0.5-0.75 g daily, and the average course of treatment is 3 (1-14) months. The plasma cortisol, urinary 17-hydroxycorticosteroids, and 17-ketol steroids were reduced in the first week after administration, and decreased significantly after 3 months (P<0.001 before taking the drug). Results: 11 cases were markedly effective, 7 cases were effective, and 3 cases were ineffective. AG’s long-term treatment of hypercortisolism is undoubtedly an effective measure to reduce clinical symptoms.