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目的探讨帕金森病(PD)合并抑郁障碍的患病率及相关危险因素。方法应用汉密尔顿抑郁量表(HAMD)对217例PD患者的抑郁状况进行评定,根据疾病特异性界定值将患者分为合并或无抑郁障碍两组;并对所有患者进行统一PD评估量表(UPDRSⅢ)、MMSE量表和39项PD问卷(PDQ-39)评分。结果PD合并抑郁障碍的患病率为21.7%(47/217),合并抑郁障碍的患者中接受抗抑郁治疗的比例为10.6%(5/47)。Logistic回归结果示合并抑郁障碍的独立危险因素是Schwab-England分级和临床分型(P均<0.01,OR分别为0.720和2.482)。抑郁障碍组患者的生活质量明显劣于对照组。结论PD合并抑郁障碍的患病率较高,并严重恶化患者的生活质量,但相应治疗并未得到医生的充分重视。严重残疾和强直-少动型明显增加PD合并抑郁障碍的危险性。
Objective To investigate the prevalence and related risk factors of Parkinson’s disease (PD) with depressive disorder. Methods Depression was assessed in 217 patients with PD by using Hamilton Depression Rating Scale (HAMD). Patients were divided into two groups according to the disease-specific definition, with or without depression. All patients were assessed with PD evaluation scale (UPDRS Ⅲ ), MMSE scale and 39 PD questionnaires (PDQ-39). Results The prevalence of PD with depressive disorder was 21.7% (47/217). The proportion of patients with depressive disorder receiving antidepressant treatment was 10.6% (5/47). Logistic regression analysis showed that the independent risk factor of depression was Schwab-England classification and clinical classification (P <0.01, OR = 0.720 and 2.482 respectively). The quality of life of patients with depressive disorder was significantly worse than that of the control group. Conclusions The prevalence of PD complicated with depression is high, and the quality of life of patients is seriously deteriorated. However, the corresponding treatment has not received the full attention of doctors. Severe disability and rigidity - less type significantly increased the risk of PD with depression.