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目的:观察思密达对静滴红霉素产生的胃肠道反应的治疗效果。方法:采用同一病例配对资料、症状评分法,对不同年龄、性别患儿50例分A组(在静滴红霉素过程中出现不同程度胃肠道反应者服用思密达)及B组(对A组患儿于下一次静滴红霉素前半小时一次性服用思密达),比较治疗前后胃肠道反应变化,采用配对资料符号秩和检验进行评估。结果:A组、B组治疗前后均有显著性差异(Z=-6.1540,P=0.0001)。结论:思密达有减轻及使红霉素产生胃肠道反应消失的治疗效果。
Objective: To observe the effect of Smecta on the gastrointestinal reaction caused by intravenous infusion of erythromycin. Methods: Using the same case matching data and symptom score method, 50 patients in different age and sex groups were divided into group A (patients taking different doses of esomeprazole during intravenous erythromycin) and group B ( A group of children in the next intravenous infusion of erythromycin once a half hours before taking Smectite), compared before and after treatment of gastrointestinal reactions, using paired data sign rank sum test to assess. Results: There was a significant difference between group A and group B before and after treatment (Z = -6.1540, P = 0.0001). Conclusion: Smectite can reduce erythromycin and gastrointestinal reaction disappeared.