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金刚胺(AmTd)是临床防治甲型流感病毒感染的有效药物。应用体外实验研究AmTd 及其类似物2-氨基金刚烷(2-NH_2-Adam)、1-硝基金刚烷(1-NO_2-Adam)及2-硝基金刚烷(2-NO_2-Adam)对丝裂原诱导的小鼠淋巴细胞增殖、IL-2诱导的 T 杀伤细胞株 CTLL 细胞增殖以及对 T 细胞亚群的影响。结果表明,AmTd 及其异构体2-NH_2-Adam 可明显抑制 T 细胞丝裂原 ConA 和 B细胞丝裂原 LPS 诱导的淋巴细胞增殖及 IL-2诱导的 CTLL 细胞增殖。对上述细胞增殖反应的50%抑制率(IC_(50))AmTd 分别为0.14,
Amantadine (AmTd) is an effective drug for clinical prevention and treatment of influenza A virus infection. The effects of AmTd and its analogues such as 2-NH_2-Adam, 1-NO_2-Adam and 2-NO 2 -Adam were studied in vitro. Mitogen-induced mouse lymphocyte proliferation, IL-2-induced T killer cell line CTLL cell proliferation and its effect on T cell subsets. The results showed that AmTd and its isomer 2-NH2-Adam could significantly inhibit LPS-induced lymphocyte proliferation and IL-2-induced proliferation of CTLL cells induced by T cells mitogen ConA and B cells. The 50% inhibition (IC 50) AmTd of the above cell proliferation response was 0.14,