论文部分内容阅读
EB病毒(EBV)是一种DNA肿瘤病毒,它与传染性单核细胞增多症(IM),burkitt’s淋巴瘤(BL),鼻咽癌(NPC)以及多克隆B细胞淋巴瘤有密切的关系。自1964年Epstein发现EBV以来已有二十余年历史。开始十年主要研究了EBV的生物学特性及血清流行病学,以后十年主要研究了EBV分子生物学以及EBV的转化机理等。近几年来,人们从分子水平探讨EBV基因组中与转化有关的片段、编码EBV抗原的基因定位以及EBV的受体等等。本文拟综述近年来EBV的研究进展。一、EBV的分子生物学研究
Epstein-Barr virus (EBV) is a DNA tumor virus that is closely related to infectious mononucleosis (IM), burkitt’s lymphoma (BL), nasopharyngeal carcinoma (NPC), and polyclonal B-cell lymphoma. It has been more than twenty years since Epstein discovered EBV in 1964. In the ten years from the beginning, the biological characteristics and seroprevalence of EBV were studied. In the following decade, the EBV molecular biology and the transformation mechanism of EBV were studied. In recent years, people have been exploring the transformation-related fragments of the EBV genome, gene localization of EBV antigens, and receptors for EBVs at the molecular level. This article intends to review the research progress of EBV in recent years. I. Molecular Biology Study of EBV