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人们经常说,老化是由于某些大分子或细胞结构缺陷积聚的结果。因为较高级有机体的生存取决于分化细胞的正常功能,所以一个重要的可能性是老化破坏了基因表达的必要控制。Wareham等在本刊中(Nature 327(6124):725,July 1987)论述了简单而有效的技术来检查小鼠老化过程中X染色体失活的稳定性。他们的结果表明在失活的X染色体上一个不活动的基因在老化过程中重新被激活的频率不断增加。这可看作是DNA水平的后生
It is often said that aging is the result of the accumulation of defects in certain macromolecules or cells. Because the survival of higher organisms depends on the normal function of differentiated cells, an important possibility is that aging destroys the necessary control of gene expression. In this publication (Nature 327 (6124):725, July 1987), Wareham et al. discuss a simple and effective technique to examine the stability of X chromosome inactivation during mouse aging. Their results show that the frequency of an inactive gene on the inactivated X chromosome is reactivated during aging. This can be seen as the epigenetic of DNA levels.