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目的探讨分化型胚胎软骨发育基因1(DEC1)蛋白在人卵巢癌中的表达和临床意义。方法通过免疫组织化学染色的方法,在110例卵巢癌组织、正常卵巢组织、卵巢良性肿瘤组织中分别检测DEC1蛋白的表达,统计分析DEC1蛋白表达高低与卵巢癌临床病理学特征间的相关性。结果 DEC1蛋白在卵巢癌组织的阳性表达率为62.73%,在卵巢良性肿瘤的阳性表达率为27.27%,而在正常卵巢组织的阳性表达率仅为19.09%,3组阳性表达率比较差异有统计学意义(χ~2=51.15,P<0.05)。DEC1蛋白在卵巢癌组织中的阳性表达与卵巢癌FIGO分期(χ~2=41.026,P<0.001)、组织学分化程度(χ~2=6.142,P=0.046)具有显著相关性、呈正相关,而与患者的年龄(χ~2=2.195,P=0.169)、卵巢癌病理学类型(χ~2=1.550,P=0.461)、淋巴结转移(χ~2=0.159,P=0.698)等均无相关性。结论 DEC1蛋白在卵巢癌组织中高表达,在正常卵巢组织和卵巢良性肿瘤中低表达;DEC1的高表达与卵巢癌疾病高组织学分期和不良分化程度呈正相关。
Objective To investigate the expression and clinical significance of differentiated embryonic cartilage developmental gene 1 (DEC1) in human ovarian cancer. Methods Immunohistochemical staining was used to detect the expression of DEC1 protein in 110 cases of ovarian cancer, normal ovarian tissue and benign ovarian tumor respectively. The correlation between the expression of DEC1 protein and clinicopathological features of ovarian cancer was statistically analyzed. Results The positive expression rate of DEC1 protein in ovarian cancer tissue was 62.73%, the positive expression rate in ovarian benign tumor was 27.27%, while the positive expression rate of DEC1 protein in normal ovarian tissue was only 19.09%. There were statistically significant differences among the three groups Significance (χ ~ 2 = 51.15, P <0.05). The positive expression of DEC1 protein in ovarian cancer tissues was positively correlated with the FIGO stage (χ ~ 2 = 41.026, P <0.001), histological differentiation (χ ~ 2 = 6.142, P = 0.046) There were no significant differences in the pathological types (χ ~ 2 = 1.550, P = 0.461) and lymph node metastasis (χ ~ 2 = 0.159, P = 0.698) Correlation. Conclusions DEC1 protein is overexpressed in ovarian cancer tissues and low in normal ovarian tissues and benign ovarian tumors. The high expression of DEC1 is positively correlated with the high histological grade and poor differentiation of ovarian cancer.