目的通过对糖尿病患者血液中硫化氢、Aβ42、BACE1的测定，研究糖尿病患者认知功能障碍与相关标志物的关系。方法实验设糖尿病认知功能障碍组，糖尿病认知功能正常组，正常对照组，每组20例。分别以敏感硫电极法测定硫化氢，ELISA检测Aβ42、BACE1含量。结果糖尿病患者体内H2S含量较正常对照明显降低（P<0.05），其中认知功能障碍组降低程度较认知功能正常组大（P0.05），而糖尿病伴认知功能障碍组体内 Aβ42、BACE1含量显著升高（P<0.05）。结论糖尿病患者体内发生H2S含量下调，正性作用于BACE1，进而上调APP/Aβ代谢，引起Aβ42的沉积，从而导致糖尿病认知功能障碍。“,”Objective To observe the relationship between diabetic cognitive dysfunction and blood H2S,BACE1,Aβ42. Methods Experimental subjects were divided into 3 groups:blank control group, simple diabetes group, diabetic cognitive dysfunction group, 20 cases of each group. 4 groups were detected concentration of H2S in sensitive sulphur electrode method and BACE1、Aβ42 in ELISA method. Results The concentration of H2S in simple diabetes group was significantly lower than those in blank control group (P<0.05), and the diabetic cognitive dysfunction group was significantly lower than simple diabetes group (P0.05), but those in diabetic cognitive dysfunction group increased significantly (P<0.05).Conclusion The concentration of H2S reduced in patients with diabetes, positive effecting on BACE1, up-regulating the expression of APP/Aβ metabolism, leading to the deposition of Aβ42, and resulted in diabetic cognitive dysfunction.