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目的观察维持性血液透析联合血液灌流治疗尿毒症的临床效果。方法采用前瞻性、随机、对照性研究。选取64例HD患者，随机分为两组。治疗组HD+HP组(n=32)采取维持性单纯血液透析(2~3)次/w,期中HD+HP(1次/月)治疗；对照组HD组(n=32)采取单纯血液透析(2~3)次/w)治疗。治疗1a。治疗组和对照组尿毒症患者进行临床疗效对比研究。结果1a观察期结束时，HD+HP组患者的CRP、PTH、β2-MG收缩压、舒张压、心率、心胸比、降压药的种类均低于HD组(均P＜0.05)；HD+HP组能显著地改善患者皮肤瘙痒、食欲下降、睡眠差的症状；患者的生活质量明显好于HD组。结论 HD+HP能显著地改善患者皮肤瘙痒、食欲下降、睡眠差的症状；清除患者体内中大分子毒素和提高生存率的效果明显优于单纯性HD。“,”Objective To investigate the clinical effect of maintenance hemodialysis (HD) combined with hemoperfusion (HP) for uremic patients. Methods 64 patients on maintenance hemodialysis were randomly assigned into 2 groups, The hemodialysis + hemoperfusion (HD+HP) group (n=32) and hemodialysis (HD) group (n=32). The paitents of the experiment group (HD+HP) were treated with maintenance hemodialysis 2-3 times per week and accepted hemoperfusion once per month, the patients of the control group (HD) accepted maintenance hemodialysis 2-3 times per week. The treatment lasted for 1 year. Results The level of CRP PTH, β2-MG, Systolic and Diastolic blood pressure, Heart rate, Cardiothoracic ratio and the kind of hypotensor were all lower in the HD+HP group (P<0.05). The patients of the HD+HP group had better quality of life than the HD group. The HD+HP group had better clinical effect than the HD group. Conclusion HD+HP could had better effect than the HD group on improving effectively pruritus, sleeping, and appetite, enhancing the clearance rate of macromolecular and hemoperfusion substances and the survival rate.