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为探索Midocalm对某些抗生素耳毒作用的防治效果,作者进行了本实验。Midocalm是β-氨基酮的产物,具有扩张血管,加强外周血运,改善脑血流,组织氧合,降低血管肌张力等作用。30只豚鼠均分为五组,依次单独腹腔内注射卡那霉素(50单位/kg);Midocalm(12mg/kg);两者同时或先后应用。注射均每日进行一次,持续14天。然后全麻下摘取耳蜗,开放骨壳,在4℃下用80％酒精固定24小时后做碱性磷酸酶染色。最后分离血管纹,铺片,光镜下用目微尺测量血管直径。另用6
To explore the effect of Midocalm on the prevention and treatment of certain antibiotic ototoxicity, the author conducted this experiment. Midocalm is a product of β-aminoketone, which has the functions of dilating blood vessels, enhancing peripheral blood flow, improving cerebral blood flow, tissue oxygenation and lowering vascular muscle tone. 30 guinea pigs were divided into five groups, followed by a single intraperitoneal injection of kanamycin (50 units / kg); Midocalm (12mg / kg); both simultaneously or successively. Injections are administered daily for 14 days. Then under general anesthesia removal of the cochlear, open the bone shell, at 4 ℃ with 80% alcohol for 24 hours after alkaline phosphatase staining. Finally, the separation of the vascular pattern, the film, light microscope with a micro-foot measurement of vascular diameter. Another 6