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目的探讨人乳头瘤病毒(HPV)在宫颈癌及癌前病变中的临床意义。方法 141例宫颈细胞学检查异常患者通过第二代杂交捕获试验(HCII)检测HPV,并实施阴道镜检查及活检。结果宫颈炎39例、CINΙ74例、CINⅡ14例、CINⅢ11例、宫颈癌3例;HPV感染67例(47.52%),且随宫颈病变程度加重HPV感染率呈增高趋势。结论 HPV感染与宫颈癌及癌前病变关系密切,且与病变严重程度有一定相关性。
Objective To investigate the clinical significance of human papillomavirus (HPV) in cervical cancer and precancerous lesions. Methods One hundred and seventy-one patients with abnormal cervical cytology were tested for HPV by second-generation hybridization capture test (HCII), and colposcopy and biopsy were performed. Results 39 cases of cervicitis, CIN7474 cases, CINⅡ14 cases, CINⅢ11 cases, cervical cancer 3 cases; HPV infection in 67 cases (47.52%), and with the severity of cervical lesions increased HPV infection rate was increased. Conclusion HPV infection is closely related to cervical cancer and precancerous lesions, and has some correlation with the severity of the disease.