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目的:加深对药物超敏综合征的认识。方法:回顾分析17例药物超敏综合征患者的临床资料。结果:17例患者均以皮疹、发热为首发症状,于用药后2～6周发生;其中伴浅表淋巴结大者12例、肝细胞损害者16例、肺损害者2例、肾损害者1例、白细胞升高者13例、血嗜酸粒细胞增多者14例;可疑致病药物为:别嘌呤醇9例、卡马西平3例、氨苯砜(DDS)3例、解热镇痛药2例。结论:临床用药过程中,如出现高热、浅表淋巴结大、血细胞异常、嗜酸粒细胞明显增高、全身性皮疹、内脏损害者应高度警惕药物超敏综合征。
Objective: To deepen the understanding of drug hypersensitivity syndrome. Methods: The clinical data of 17 patients with drug hypersensitivity syndrome were retrospectively analyzed. Results: All the 17 patients had rash and fever as their first symptom, and they developed at 2-6 weeks after treatment. Among them, 12 cases had superficial lymph nodes, 16 cases of hepatocyte damage, 2 cases of lung damage, 1 kidney damage Cases, leukocytosis in 13 cases, 14 cases of blood eosinophilia; suspicious pathogenic drugs: allopurinol in 9 cases, 3 cases of carbamazepine, dapsone (DDS) in 3 cases, antipyretic and analgesic Medicine 2 cases. Conclusion: During the course of clinical medication, hypersensitivity, superficial lymph nodes, abnormal blood cells and eosinophils were significantly increased. Patients with systemic rash and visceral injuries should be highly alert to drug hypersensitivity syndrome.