论文部分内容阅读
在临床上发现癌,其直径至少需达到5mm,这样大小的癌至少由10~8个以上的细胞组成。一个细胞发展成这种癌至少需反复进行近30次的分裂。在此期间正是“阶段性的”癌化过程。因此,弄清癌变的最初阶段,是正确理解癌本身和制癌的重要步骤。为阐明癌发生的初期机制,目前已建立了几种体外癌化细胞系。作为癌化细胞定量系统,只有叙利亚倉鼠胎儿(SHE)细胞和小鼠C_3H10T1/2细胞两个系统受到确认。前者是正常细胞,后者是已获得无限增殖能力的细胞。虽使用细胞不同,但两者都是伴有癌化的正常纤维母细胞,都以丧失严格的接触增殖抑制能
Cancers are clinically found to have a diameter of at least 5 mm. Cancers of this size are composed of at least 10 to 8 cells. A cell that develops this type of cancer must undergo at least 30 divisions over and over again. During this period it was a “staged” cancerization process. Therefore, to understand the initial stage of cancer is an important step to correctly understand the cancer itself and cancer. To elucidate the initial mechanism of carcinogenesis, several in vitro cancerous cell lines have been established. As a cancerous cell quantification system, only two systems, Syrian hamster fetus (SHE) cells and mouse C3H10T1/2 cells, were confirmed. The former is a normal cell, and the latter is a cell that has acquired infinite proliferation ability. Although different cells are used, both are normal fibroblasts accompanied by cancer, and all of them lose the strict contact proliferation inhibitory energy.