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生长因子受体通过激活本身的酪氨酸激酶活性而起作用,其结果是导致细胞内特定的底物磷酸化。有些生长因子还能刺激脂代谢,这一过程的机制及其生理学上的重要性在相当一段时间是不清楚的,但最近的研究对此作了部分回答。有关多磷酸肌醇(PPI)水解机制方面的两个问题已经阐明。首先,由于磷脂酶C(PLC)效应器及其活化机制是不同的,使得表面上看来相同的反应实际上是由两类不同受体的活化而启动的。已知PLC可分为α,β,γ和δ4种。用生长因子受体时,所涉及的PLC是γ_1,它不能与G蛋白反应,但能与之
Growth factor receptors act by activating their own tyrosine kinase activity, which results in the phosphorylation of specific substrates within the cell. Some growth factors can also stimulate lipid metabolism. The mechanism of this process and its physiological importance are unclear for quite some time, but recent studies have partially answered this. Two questions regarding the mechanism of hydrolysis of polyphosphoinositide (PPI) have been elucidated. First, because the phospholipase C (PLC) effector and its activation mechanism are different, the seemingly identical reactions on the surface are actually initiated by the activation of two different types of receptors. Known PLC can be divided into α, β, γ and δ 4 species. When using a growth factor receptor, the PLC involved is γ_1, which cannot react with the G protein, but can