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目的观察硫酸软骨素(CS)对慢性酒精损伤大鼠的抗氧化作用,并探讨其可能的发生机制。方法对雄性Wistar大鼠分别进行酒精和药物(纳洛酮和不同剂量的硫酸软骨素)处理,观察大鼠肝组织病理变化及GSH-Px,SOD,MDA等肝脏指标。利用统计学分析方法分析药物的抗氧化性能。结果酒精模型组大鼠肝细胞脂肪变性明显,多灶性肝细胞嗜酸性变,灶性坏死,肝细胞排列紊乱,同时血清及肝组织GSH-Px和SOD活性均明显降低,MDA含量则明显升高。从肝结构病理学观察,硫酸软骨素各剂量组,肝组织结构均得到不同程度的改善,同时硫酸软骨素各剂量组大鼠血清及肝组织GSH-Px和SOD活性,与酒精模型组比较均有不同程度的提高,而MDA含量均明显降低。结论硫酸软骨素对慢性酒精损伤大鼠机体氧化损伤具有一定的保护作用,其抗氧化功能可能通过增强大鼠体内抗氧化酶活性,改善肝组织病理损伤来实现。
Objective To observe the anti-oxidative effect of chondroitin sulfate (CS) on rats with chronic alcohol injury and to explore its possible mechanism. Methods Male Wistar rats were treated with alcohol and drugs (naloxone and different doses of chondroitin sulfate) to observe the pathological changes of liver tissue and liver indicators such as GSH-Px, SOD and MDA. Analyze the anti-oxidation properties of drugs by statistical analysis. Results The hepatic steatosis of alcoholic rats was obvious, and the eosinophilic changes, focal necrosis and hepatocellular disorganization of multifocal hepatocytes were disordered. At the same time, the activities of GSH-Px and SOD in serum and liver tissue were significantly decreased, but MDA content was significantly increased high. From the liver histopathology observation, the chondroitin sulfate dosage groups and the liver tissue structure all got the different degrees of improvement. At the same time, the GSH-Px and SOD activities in the serum and liver tissue in each dose of chondroitin sulfate group were significantly lower than those in the alcohol model group Have different degrees of increase, while the MDA content were significantly reduced. Conclusion Chondroitin sulfate has a protective effect on oxidative damage in rats with chronic alcohol injury, and its anti-oxidant function may be achieved through enhancing antioxidant enzyme activity and improving pathological damage of liver tissue in rats.