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目的分析2002-2010年上海市浦东新区0~14岁儿童恶性肿瘤的流行病学特征。方法利用上海市肿瘤登记报告和随访管理系统收集儿童恶性肿瘤的发病与死亡资料,并将数据信息与生命统计死因推断核对。采用国际儿童肿瘤分类系统(ICCC-3)进行归类分析。结果 2002-2010年浦东新区新诊断儿童恶性肿瘤病例283例,粗发病率为121.86/100万,标化发病率为124.03/100万。0~4岁组发病率最高。发病构成前三位为白血病、中枢神经系统(central nervous system,CNS)肿瘤及淋巴瘤。同期间儿童恶性肿瘤死亡病例121例,粗死亡率为52.10/100万,标化死亡率为54.19/100万。0~4岁组与5~9岁组死亡率较高且基本相同,10~14岁组相对较低。死亡构成前三位为CNS肿瘤、白血病及恶性骨肿瘤。结论浦东新区儿童恶性肿瘤发病率及死亡率都比较低。发病率低于西方国家,但稍高于全上海市水平,主要瘤别分布一致,不同性别和年龄别发病率不同。
Objective To analyze the epidemiological characteristics of malignant tumors in children aged 0-14 in Shanghai Pudong New Area from 2002 to 2010. Methods Shanghai Cancer Registry and Follow-up Management System were used to collect the data on the incidence and death of children with malignant tumors, and the data and life statistics were inferred. The international children’s tumor classification system (ICCC-3) for classification analysis. Results A total of 283 new cases of childhood malignancies were diagnosed in Pudong New Area in 2002-2010. The crude incidence rate was 121.86 / 1 million with the standardization rate of 124.03 / 1 million. 0 to 4 years old group the highest incidence. The top three pathogenesis are leukemia, central nervous system (CNS) tumors and lymphomas. During the same period, 121 cases of malignant tumor deaths in children, the crude death rate was 52.10 / 1 million, the standardization mortality was 54.19 / 1 million. Mortality rates were similar among 0 to 4 years old group and 5 to 9 years old group, but relatively low in 10 to 14 years old group. The top three deaths were CNS tumor, leukemia and malignant bone tumor. Conclusion The incidence and mortality rate of malignant tumor in children in Pudong New Area are relatively low. The morbidity was lower than that in western countries, but slightly higher than that in Shanghai. The distribution of major tumor was consistent and the incidence was different for different genders and ages.