急性肾小管坏死(ATN)是广义急性肾衰竭综合征的主要病因,其发病率和病死率均很高,不仅给家庭带来了沉重的经济负担和心理压力,对国家也造成了巨大的资源消耗和社会负担。然而,ATN的病理生理过程十分复杂,因此治疗手段缺乏针对性。近年来大量研究发现细胞因子、炎性因子及生长因子等化学介质在ATN的发生发展过程中发挥着十分重要的作用,通过干预某些化学介质的表达可以达到治疗目的,这对于肾脏疾病是一个很有发展前景的方法。现从化学介质的角度对目前ATN的研究予以综述。 Acute tubular necrosis (ATN) is the main cause of generalized acute renal failure syndrome, its morbidity and mortality rates are high, not only to bring a heavy financial burden and psychological pressure on the family, but also caused tremendous resources for the country Consumption and social burdens. However, the pathophysiological process of ATN is very complex, so the lack of targeted treatment. In recent years, a large number of studies have found that cytokines, inflammatory cytokines and growth factors and other chemical mediators play a very important role in the development of ATN. The therapeutic purpose can be achieved by interfering with the expression of certain chemical mediators. This is a kidney disease Very promising way. The current research on ATN is reviewed from the perspective of chemical media.