慢性粒细胞性白血病急性变(慢粒急变)多以在原病基础上恶化起病。本例以多部位反复浸润形成包块伴溶骨改变经过一定潜伏期再出现全身性表现。患者女,35岁,首次入院时间为1989年4月10日。病人于三年前在本院门诊经周围血象、骨髓象确诊为慢粒,pH′+,经嘧啶苯芥(合520)治疗完全缓解,随访观察三年病情稳定。入院前20天,病人感后背部钝痛,经胸片检查:右肺右上圆形阴影, Acute chronic myeloid leukemia (CML) and more to the original disease on the basis of deterioration of onset. In this case repeated infiltration of multiple sites to form a mass with osteolytic changes after a certain latency and then appear systemic manifestations. Female, 35 years old, first admitted to hospital on April 10, 1989. Patients in our hospital three years ago by the peripheral blood, bone marrow as diagnosed as slow granules, pH ’+, pyrimidine benzene mustard (combined 520) treatment of complete remission, follow-up observation of three years in stable condition. 20 days before admission, the patient feeling back dull pain, chest X-ray examination: the right upper right circular shadows,