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作者报告一例女性,67岁,右乳房的乳头部结痴、渗液和局部发生无症状硬块角样物5周余而来就诊。体检发现该乳头局部硬块、肥厚、致密似角状,3个月内曾脱落及重新生长几次,除去皮角,乳头处无溃疡形成,局部发红有光泽,基底组织无硬块或结节。乳头切除病检,发现表皮致密的过度角化病,含有多数孤立或成群的圆形大核细胞和丰满的苍白色胞浆。特殊染色有糖原,但缺乏黑素和粘蛋白,其下真皮含有致密的炎性浸润,结缔组织的基质中,没有发现乳腺导管或导管癌细胞。虽然,
The authors report a case of a 67-year-old female who presented with an infection in the papillary node of the right breast, exudate, and an asymptomatic lumpy keratoderma for more than five weeks. Physical examination revealed that the nipple was partially lumpy, hypertrophic, and densely horny. She had fallen off and re-growth several times within 3 months. The skin angle was removed, no ulceration was formed at the nipple, local redness was shiny, and the basement had no lump or nodule. Examination of the nipples revealed a dense hyperkeratosis of the epidermis, containing mostly isolated or clustered round large nuclear cells and plump pale cytoplasm. Special stains are glycogen, but lack melanin and mucin, and the lower dermis contains dense inflammatory infiltrates. No mammary duct or ductal cancer cells have been found in the connective tissue matrix. although,