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目的观察甲氨蝶呤(MTX)联合桂枝茯苓胶囊治疗异位妊娠的效果。方法 85例异位妊娠患者随机分成两组,观察组(n=43)给予MTX50mg/m2单次肌内注射,同时加服桂枝茯苓胶囊3粒,3次/d,共4周;对照组(n=42)给予MTX50mg/m2单次肌内注射。观察两组疗效及不良反应情况。结果观察组治疗成功38例(88.3%);对照组治疗成功34例(81.0%),两组治疗成功率比较无明显差异(P>0.05)。观察组血β-HCG转阴所需时间明显短于对照组(P<0.05),平均住院天数与附件包块消失时间明显少于对照组(P<0.01)。观察组患者输卵管再通率高于对照组(P<0.05)。结论 MTX联合桂枝茯苓胶囊治疗异位妊娠,能促进血β-HCG下降,缩短了住院天数,并且很好的保留了患者的生育功能,是一种较好的保守治疗方法。
Objective To observe the effect of methotrexate (MTX) and Guizhi Fuling capsule in the treatment of ectopic pregnancy. Methods 85 cases of ectopic pregnancy were randomly divided into two groups. The observation group (n = 43) received single intramuscular injection of MTX50mg / m2. At the same time, three capsules of Guizhi Fuling capsule were added three times a day for 4 weeks. (n = 42) were given a single intramuscular injection of MTX 50 mg / m2. The curative effect and adverse reaction of two groups were observed. Results 38 cases (88.3%) in the observation group were treated successfully, 34 cases (81.0%) in the control group were successful, there was no significant difference in the success rate between the two groups (P> 0.05). The time required for negative β-HCG in the observation group was significantly shorter than that in the control group (P <0.05), and the average duration of hospital stay and disappearance of the appendix mass were significantly less than those in the control group (P <0.01). The tubal recanalization rate in the observation group was higher than that in the control group (P <0.05). Conclusion MTX combined with Guizhi Fuling capsule treatment of ectopic pregnancy, can promote blood β-HCG decreased, shorten the length of stay, and well retained the patient’s reproductive function, is a better conservative treatment.