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妊娠期间孕妇通过饮用咖啡、茶和可乐(cola)而摄入咖啡因,先前研究提示妊娠时高咖啡因摄入可致胎儿在子宫内发育迟缓和早产。此外,对心血管、呼吸及中枢神经系统产生影响。本前瞻性研究旨在进一步阐明妊娠期间高咖啡因摄入引起孕妇后代的发病率。对象和方法:1985～1987年作者在Los Angeles医疗中心采集154例足月胎儿出生后即刻的尿样,进行咖啡因、乙醇、可卡因、麻醉剂和巴比妥酸盐的尿毒学测定,并在测定后通过一名不知尿测定结果的医生获取孕妇服用咖啡因、药物和乙醇的既往史。研究对象分两组:Ⅰ组为咖啡因组,系尿测定仅示咖啡
Pregnant women consume caffeine by drinking coffee, tea and cola during pregnancy. Previous studies suggested that high caffeine intake during pregnancy may cause delayed development and premature birth in the womb. In addition, cardiovascular, respiratory and central nervous system effects. The purpose of this prospective study is to further elucidate the incidence of offspring of pregnant women caused by high caffeine intake during pregnancy. Subjects and Methods: From 1985 to 1987, the authors collected urine samples from 154 full-term fetuses at the Los Angeles Medical Center to determine urinary toxicity of caffeine, ethanol, cocaine, anesthetics and barbiturates. Through a doctor who did not know the urinalysis result, she obtained the past history of pregnant women taking caffeine, drugs and alcohol. The subjects were divided into two groups: group Ⅰ was caffeine group, Department of urine test showed only coffee