我们从多种靛玉红衍生物中筛选出治疗慢粒有效药物N′-乙酰靛玉红。用N′-乙酰靛玉红治疗慢粒27例,完全缓解12例(44.44％),部份缓解14例(51.85％),进步1例(3.71％),缓解率96.29％,有效率100％,治疗9.52±6.20天后脾脏开始缩小,19.62±12.22天外周血白细胞数开始下降;达到最佳疗效(缓解)平均为87.62天,最短28天,最长206天;有5例出现腹胀、腹痛、大便次数增多,食欲不振等反应,但都能坚持用药,本组病例已发生急变者9例(33.3％)。临床研究结果表明,N′-乙酰靛玉红对慢粒具有良好疗效,不良反应轻微,优于靛玉红,值得进一步研究。 We have screened N’-acetyl-indirubin, a potent slow-acting drug, from many indirubin derivatives. There were 27 cases of slow granules treated with N’-acetyl-indirubin in 12 cases (44.44%), 14 cases (51.85%) partially relieved, 1 case (3.71%) improved, the response rate was 96.29% , The treatment of 9.52 ± 6.20 days after the spleen began to shrink, the number of peripheral white blood cells began to decline 19.62 ± 12.22 days; to achieve the best effect (remission) averaged 87.62 days, the shortest 28 days, the longest 206 days; 5 cases of abdominal distension, abdominal pain, Stool frequency increased, loss of appetite and other reactions, but can insist on medication, this group of patients have occurred in 9 cases (33.3%). Clinical studies have shown that N’-acetyl-indirubin has good curative effect on slow granules, with mild adverse reactions, which is superior to indirubin and deserves further study.