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目的:观察牛黄解毒滴丸的解热镇痛和抗炎作用方法:采用2,4-二硝基酚大鼠致热法观察其解热作用;小鼠扭体法、热板刺激法观察其镇痛作用;小鼠耳部肿胀法、大鼠蛋清足肿胀法观察其抗炎作用。结果:牛黄解毒滴丸显著降低2,4-二硝基酚所致大鼠升高的体温;明显减轻和抑制热板所致的小鼠疼痛及醋酸所致的小鼠扭体反应;抑制二甲苯所致的小鼠耳肿胀和蛋清所致的大鼠足肿胀。结论:牛黄解毒滴丸对实验大鼠、小鼠具有良好的解热、镇痛和抗炎作用。
OBJECTIVE: To observe the antipyretic, analgesic and anti-inflammatory effects of Niuhuangjiedu Dropping Pill.Methods: The antipyretic effect of 2,4-dinitrophenol rat was observed by pyrogenic method and the writhing and hot-plate stimulation Analgesic effect; mouse ear swelling method, rat egg white swollen method to observe its anti-inflammatory effect. Results: Niuhuang Jiedu Dripping Pills significantly reduced the body temperature induced by 2,4-dinitrophenol in rats, relieved and suppressed the pain caused by hot plate and the writhing reaction in mice induced by acetic acid, Toluene-induced mouse ear swelling and egg white-induced rat foot swelling. Conclusion: Niuhuang Jiedu Dropping Pills has good antipyretic, analgesic and anti-inflammatory effects on experimental rats and mice.