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对一硝基苯甲酰还原青蒿素(简称蒿苯酯Artenibenzoate)是青蒿素的衍生物。实验证明,实验动物于感染日本血吸虫尾蚴后d7开始服药,每周一次,连服4—6次,对小鼠、家兔及犬体内的血吸虫童虫有明显杀灭效果。小鼠300mg/kg连服4次的减虫率为89.1％;家兔40mg/kg连服8次和80mg/kg边服6次的减虫率分别为99.2％和100％;犬45mg/kg连服4次的减虫率为97.5％。用等毒剂量和等剂量比较蒿苯酯、呋喃丙胺和吡喹酮的杀灭血吸虫童虫效果,以蒿苯酯为最佳。蒿苯酯对血吸虫童虫表皮作用的扫描电镜观察,发现给药后童虫发育停滞,虫体变
The reduction of mononitrobenzoyl-artemisinin (Artenibenzoate for short) is a derivative of artemisinin. Experiments show that experimental animals infected with Schistosoma japonicum cercariae after d7 medication once a week, and even served 4-6 times, on mice, rabbits and dogs Schistosoma schistosomiasis significantly kill effect. The worm reduction rate was 89.1% in mice treated with 300 mg / kg for 4 times and 99.2% and 100% for dogs given 40 mg / kg for 8 times and 80 mg / kg for 6 times respectively. The dogs were treated with 45 mg / kg Even the service 4 times the worm reduction rate was 97.5%. Compare the effect of artesunate, furanpropylamine and praziquantel to kill Schistosoma japonicum by equimolar doses and equal doses, with oxaprozin being the best. Scanning electron microscopy observation of the effect of artesunate on the epidermis of Schistosoma japonicum showed that the development of schistosomiasis was stagnant and the parasites changed