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作者认为三尖杉酯碱对瘤细胞DNA合成的抑制机制与DNA合成特异抑制剂不同,与蛋白质合成特异抑制剂既有相似之处也有不同之点。该药对DNA合成的抑制,一为DNA合成系统某些环节直接被抑制,另一为蛋白质合成受到抑制。
The authors believe that the inhibitory mechanism of harringtonine on tumor cell DNA synthesis is different from that of DNA synthesis specific inhibitors, and there are similarities and differences with protein synthesis specific inhibitors. The drug’s inhibition of DNA synthesis is a direct inhibition of certain aspects of the DNA synthesis system, and the inhibition of protein synthesis.