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采用豌豆凝集素亲和交叉免疫电泳自显影法（ＰＳＡＡｆｆｉｎｏ－ｃｒｏｓｓｅｄ－ｉｍｍｕｎｏｅｌｅｃｔｒｏｐｈｏｒｅｓｉｓａｕｔｏｒａｄｉｏ－ｇｒａｐｈｙ，ＰＳＡ－Ａｆｆ－ＣＩＥＡ），测定了６３例原发性肝癌及１８例良性肝病患者的血清ＡＦＰ异质体。肝癌组ＡＦＰ－ＲＰ均值明显高于良性肝病组（Ｐ＜０．０１）．以ＡＦＰ－ＲＰ＞２５％为阳性，总阳性率为９０．５％。其中２０例患者ＡＦＰ＜４００ｕｇ／Ｌ，１８例ＡＦＰ异质体阳性，阳性率为９０．０％；４３例患者ＡＦＰ＞４００ｕｇ／Ｌ，３９例ＡＦＰ异质体阳性，阳性率９０．７％。ＡＦＰ高浓度与低浓度肝癌患者ＡＦＰ异质体的阳性率相近（Ｐ＞０．０５），说明ＡＦＰ异质体对肝癌的诊断具有特异性，尤其是ＡＦＰ低浓度持续阳性的患者，更具有较高的诊断价值。
Using PSAAffino-crossed-immunoelectrophoresisautoradio-graphy (PSA-Aff-CIEA), serum AFP heterogeneity was determined in 63 patients with primary liver cancer and 18 patients with benign liver disease. The mean AFP-RP of liver cancer group was significantly higher than that of benign liver disease group (P<0.01). AFP-RP>25% was positive and the total positive rate was 90.5%. Among them, 20 patients had AFP<400ug/L, 18 cases of AFP heterogeneity, positive rate of 90.0%; 43 cases of AFP>400ug/L, 39 cases of AFP heteroplasmy positive, the positive rate was 90.7%. The positive rate of AFP heterogeneity between high and low concentrations of AFP patients is similar (P>0.05), indicating that AFP heterogeneity is specific for the diagnosis of liver cancer, especially in patients with persistently positive AFP at low concentrations. High diagnostic value.