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[目的]探讨脊柱转移性肿瘤患者腰椎骨密度与椎体骨折的关系。[方法]以脊柱转移性肿瘤并病变椎体骨折的患者25例作为病例组,脊柱转移性肿瘤椎体骨折的患者25例作为对照组,并按年龄、性别与病例组进行频数匹配。利用单光子计算机断层扫描(SPECT)/CT仪测量骨密度。利用t检验比较两组间骨密度差异,并以多因素Logistic回归计算OR值与95%CI描述骨密度与椎体骨折发生风险的关系。[结果]病例组腰椎骨密度为(178±46)mg/cm3,对照组为(174±48)mg/cm3,两组比较,差异无统计学意义(t=0.30,P=0.788)。将两组患者骨密度统一排序以P25和P752个四分位数为分界,把患者分成高骨密度、中骨密度、低骨密度,多因素Logistic回归分析结果显示,经性别、年龄调整后,低骨密度患者骨折风险是高骨密度者的2.35倍(95%CI:1.02~17.37)。[结论]脊柱转移性肿瘤患者腰椎骨密度可能与椎体骨折有关。
[Objective] To investigate the relationship between lumbar vertebral bone mineral density (BMD) and vertebral fractures in patients with spinal metastases. [Method] Twenty-five patients with metastatic spondylolisthesis and vertebral fracture were selected as the case group and 25 patients with spinal metastatic vertebral fracture as the control group. Frequency matching was performed according to age, gender and case group. Bone mineral density was measured using a single photon computed tomography (SPECT) / CT scanner. The differences of BMD between the two groups were compared by t-test. The relationship between BMD and the risk of vertebral fractures was described by multivariate logistic regression analysis and OR value of 95% CI. [Results] The BMD of the lumbar vertebrae was (178 ± 46) mg / cm3 in the case group and (174 ± 48) mg / cm3 in the control group. There was no significant difference between the two groups (t = 0.30, P = 0.788). The two groups of patients with a unified ranking of bone mineral density P25 and P752 quartiles as the boundary, the patients were divided into high bone mineral density, low bone mineral density, multivariate logistic regression analysis showed that by gender and age adjusted, Patients with low BMD had a 2.35-fold higher risk of fractures (95% CI: 1.02 to 17.37) than those with high BMD. [Conclusion] The lumbar spine BMD may be related to vertebral fractures in patients with spinal metastases.