论文部分内容阅读
在美国,以玻璃疣(drusen)为特征的与年龄相关的黄斑变性(AMD),是老年人失明的最常见原因。10％～20％AMD患者,由于脉络膜新生血管(CNV)而致严重视力丧失。此外,有1眼患CNV者,在5年内其另眼也有发生新生血管膜的高度危险。黄斑光凝研究组曾经证实,应用激光治疗可有效减少血管造影证实有新生血管病变患者的视力丧失。然而,激光治疗也可导致永久性旁中心或中心暗点,血管新生的复发率可高达70％。对于CNV所发生的大的中心凹下新生血管膜,或边界不清的新生血管膜,目前尚无有效满意的治疗。因此,迫切需要研究阻止新生血管膜的生长和发展,或阻止CNV的复发。
In the United States, age-related macular degeneration (AMD), which is characterized by drusen, is the most common cause of blindness in the elderly. In 10% to 20% of AMD patients, severe vision loss results from choroidal neovascularization (CNV). In addition, a CNV was observed in one eye and a new high risk of neovascular membrane occurred in another eye within 5 years. Macular degeneration group has confirmed that the application of laser treatment can effectively reduce angiography confirmed neovascular lesions in patients with loss of vision. However, laser treatment can also result in permanent paracentesis or dark spots, with up to 70% recurrence of angiogenesis. There are no effective treatments for the large subfoveal neovascular membrane in CNV or the unclear borderline neovascular membrane. Therefore, there is an urgent need to study whether to prevent the growth and development of neovascular membranes or to prevent the recurrence of CNV.