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目的:探讨术前D-二聚体(D-dimer)和血小板(PLT)计数与局部晚期食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)临床病理特征的相关性及预后价值。方法:测定99例局部晚期ESCC患者(食管癌组)及30例健康体检者(对照组)血浆D-dimer和PLT水平并进行比较,并分析其与ESCC临床病理因素之间关系及预后价值。结果:食管癌组血浆D-dimer、PLT水平高于健康对照组(P<0.05)。食管癌组D-dimer与淋巴结转移、TNM分期有关,而PLT与ESCC临床病理特征无关。单因素分析提示D-dimer、淋巴结转移、TNM分期与无疾病进展时间(disease free survival,DFS)和总体生存时间(overall survival,OS)相关,而多因素分析仅提示D-dimer是局部晚期ESCC患者的独立危险预后因素。结论:D-dimer增高与淋巴结转移和TNM分期有关,D-dimer可作为评判局部晚期ESCC预后的独立指标,为ESCC个体化治疗提供参考价值。
Objective: To investigate the correlation and prognostic value of preoperative D-dimer and platelet count (PLT) with clinicopathological features of locally advanced esophageal squamous cell carcinoma (ESCC). Methods: The plasma levels of D-dimer and PLT in 99 ESCC patients (esophageal cancer group) and 30 healthy controls (control group) were measured and compared with each other, and their relationship with the clinicopathological factors and prognostic value of ESCC were analyzed. Results: The plasma levels of D-dimer and PLT in esophageal cancer group were higher than those in healthy control group (P <0.05). D-dimer in esophageal cancer was related to lymph node metastasis and TNM staging, while PLT was not related to clinicopathological features of ESCC. Univariate analysis suggested that D-dimer, lymph node metastasis, TNM stage were associated with disease free survival (DFS) and overall survival (OS), whereas multivariate analysis only suggested that D-dimer was a locally advanced ESCC Patients with independent risk prognostic factors. Conclusions: The increased D-dimer is related to lymph node metastasis and TNM staging. D-dimer can be used as an independent index to evaluate the prognosis of locally advanced ESCC, and provide reference value for individualized treatment of ESCC.