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目的:探讨食管鳞癌患者术前血清HGF、VEGF-C的表达及临床意义。方法:以手术组57例食管鳞癌患者和对照组20例健康体检者为研究对象,所有患者术前抽取血清标本,酶联免疫吸附反应方法(ELISA法)测定血清HGF、VEGF-C的表达水平。结果:食管癌患者组治疗前的血清HGF和VEGF-C表达水平均明显高于正常对照组(P<0.01)。血清HGF和VEGF-C的表达均不受性别、年龄、分化程度和病变部位的影响。血清HGF表达水平受病变长度、T分期和临床分期影响,而血清VEGF-C表达水平受T分期、N分期和临床分期影响。直线相关分析显示血清HGF与VEGF-C表达水平呈正相关。血清HGF水平<406pg/mL和≥406pg/mL患者的中位生存期分别是24.6个月和13.9个月,2年生存率分别是85%和45%(P<0.05)。多因素Cox比例风险模型分析显示,临床分期和血清HGF与VEGF-C表达水平是影响预后的独立因素。结论:食管鳞癌患者术前血清HGF和VEGF-C的高水平表达可作为食管癌术后患者预后不良的独立危险因素。
Objective: To investigate the expression and clinical significance of preoperative serum HGF, VEGF-C in patients with esophageal squamous cell carcinoma. METHODS: A total of 57 patients with esophageal squamous cell carcinoma and 20 healthy controls in the control group were included in the surgery group. Serum samples were taken from all patients before operation, and the expression of HGF and VEGF-C in serum was determined by enzyme-linked immunosorbent assay (ELISA). Level. Results: The expression levels of serum HGF and VEGF-C in the esophageal cancer patients before treatment were significantly higher than those in the normal control group (P<0.01). The expression of serum HGF and VEGF-C were not affected by gender, age, degree of differentiation, and location of lesions. Serum HGF expression levels are affected by lesion length, T stage, and clinical stage, while serum VEGF-C expression levels are influenced by T stage, N stage, and clinical stage. Linear correlation analysis showed a positive correlation between serum HGF and VEGF-C expression levels. The median survival of patients with serum HGF levels < 406 pg/mL and ≥ 406 pg/mL were 24.6 and 13.9 months, respectively, and the 2-year survival rates were 85% and 45%, respectively (P < 0.05). Multivariate Cox proportional hazards model analysis showed that clinical stage and serum HGF and VEGF-C expression levels are independent factors that affect the prognosis. Conclusion: High-level expression of serum HGF and VEGF-C in patients with esophageal squamous cell carcinoma can be used as an independent risk factor for poor prognosis of esophageal cancer patients.