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本文报道了以Amsacrine或柔红霉素为基础的联合化疗对16例初治急性早幼粒细胞白血病(APL)的疗效。患者均为原发性APL,中位数年龄31岁(范围:20-71)。12例于治疗前、4例在治疗中出现DIC症状。化疗分为二组:(1)AAT方案:Amsacrine190-225mg/m~2/日,连用3天;Ara-c 25 mg/m~2/日静注第一天,以后160-200mg/m~2/日,静滴,连用5天;6-TG100mg/m~2/12小时,连用10次。(2),
This article reported the efficacy of combination chemotherapy with Amsacrine or daunorubicin on 16 newly diagnosed acute promyelocytic leukemia (APL). All patients were primary APL with a median age of 31 years (range: 20-71). Twelve patients had symptoms of DIC before treatment and 4 in treatment. Chemotherapy was divided into two groups: (1) AAT regimen: Amsacrine 190-225 mg/m~2/day for 3 days; Ara-c 25 mg/m~2/day intravenous infusion for the first day and later 160-200 mg/m~ 2/day, intravenous infusion, continuous use for 5 days; 6-TG 100 mg/m~2/12 hours, continuous use 10 times. (2),