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据报道甲氰咪胍有抗瘙痒及抗肿瘤作用,作者用之治疗2例蕈样肉芽肿,获得完全的缓解。例1,62岁,男。1979年在躯干及四肢有很多钱币形及不规则的红至棕色硬结性斑块。组织学检查有小的Pautrler微脓疡,符合皮肤T细胞性淋巴瘤(CTCL)。局部应用氮芥后发生严重的接触性皮炎而停用。用甲氧呋豆素(Methoxsalen)光化疗无效,肿瘤发展为几个斑块。双腋及左锁骨上窝有淋巴结肿大。电子束治疗(4000拉德)产生完全但很短暂的缓解;经治疗2周后,瘙痒及多发性新的皮肤斑块又复发。次年口服苯丁酸氮芥,标准疗程的
It has been reported that cimetidine has antipruritic and antitumor effects, and the authors used it to treat 2 cases of mycosis granulomatosis and achieved complete remission. Example 1, 62 years old, male. In 1979 there were many coins and irregular red-to-brown hard-coated plaques on the trunk and limbs. Histological examination had small Pautrler micropus, consistent with cutaneous T-cell lymphoma (CTCL). Severe contact dermatitis was disabled after topical application of nitrogen mustard. Phototherapy with Methoxsalen was ineffective and tumors developed into several plaques. There are enlarged lymph nodes in the double iliac crest and the left supraclavicular fossa. Electron beam therapy (4000 rads) produced a complete but very brief remission; after 2 weeks of treatment, itching and multiple new skin patches recurred. Oral chlorambucil for the following year, standard course of treatment