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曾报道口服环孢多肽对慢性肠道炎症有一定疗效,因环孢多肽对肾脏有毒性,宜低剂量给药。因此,作者研究环孢多肽局部用药在患直肠疾病的病人中对粘膜炎症的作用。 8例受试者均患溃疡性结肠炎或慢性活动性直肠炎,采用局部皮质甾醇类激素和5- 对氨基水杨酸治疗无效。患病时间为6年(2～22年)。试验期间,每晚采用环孢多肽保留灌肠剂(每100ml中含环孢多肽250mg、山梨醇5.5g、羧甲基纤维素钠600mg)灌肠。在首次使用灌肠剂后,对7例病人进行了单剂量药动学研究。并定期抽取血液标本,进行全血环孢多肽浓度检测。用药2周
It has been reported oral cyclosporin for chronic intestinal inflammation have a certain effect, because of cyclosporin toxic to the kidneys, low-dose should be administered. Therefore, the authors investigated the effect of topical use of cyclosporin on mucosal inflammation in patients with rectal diseases. All 8 subjects had ulcerative colitis or chronic active proctitis. Treatment with topical corticosteroids and 5-aminosalicylic acid was not effective. The sick time is 6 years (2 to 22 years). During the experiment, cyclosporin retention enema (250 mg cyclosporin per 100 ml, sorbitol 5.5 g, sodium carboxymethylcellulose 600 mg) enema was applied overnight. After the first dose of enema, a single dose pharmacokinetic study of seven patients was performed. Blood samples were drawn regularly to detect whole blood cyclosporin concentration. Medication for 2 weeks