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目的:探讨妊娠期高血压疾病(hypertensive disorder in pregnancy,HDP)对新生儿脐血食欲素水平的影响及食欲素与新生儿出生体质量、体质量指数、头围、身长之间的关系。方法:妊娠期高血压疾病母亲所生新生儿65例,按第7版妇产科学妊娠期高血压疾病诊断标准分为3组:妊娠期高血压组(HDP 1)24例、子痫前期轻度组(HDP 2)23例、子痫前期重度组(HDP 3)18例,正常对照组41例。采用放射免疫分析法(Radioimmunoassay RIA)测定脐血食欲素水平,并分析食欲素水平与新生儿出生体质量、体质量指数(Birth Mass Index BMI)、头围、身长的相关性。结果:①妊娠期高血压疾病组新生儿脐血食欲素水平高于正常对照组,且随母亲妊娠期高血压疾病程度的加重呈进行性升高,组间比较有统计学意义(F=3.962,P<0.05)。②妊娠期高血压疾病组新生儿出生体质量、体质量指数低于正常对照组,且随母亲妊娠期高血压疾病程度的加重呈进行性下降,组间比较有统计学意义(F=6.141,P<0.01;F=2.678,P<0.05);头围、身长组间比较有统计学意义(F=5.483,P<0.01;F=6.352,P<0.01),表现为子痫前期重度组新生儿头围、身长明显低于正常对照组。③妊娠期高血压疾病组新生儿脐血食欲素水平与出生体质量、体质量指数、头围、身长均呈负相关(r=-0.342,P<0.05;r=-0.317,P<0.05;r=-0.334,P<0.05;r=-0.287,P<0.05)。结论:妊娠期高血压疾病母亲所生新生儿脐血中存在食欲素,食欲素水平随母亲妊娠期高血压疾病程度的加重而进行性升高,食欲素与胎儿生长发育明显相关。
Objective: To investigate the effects of hypertensive disorder in pregnancy (HDP) on umbilical blood orexin levels in neonates and the relationship between orexin and newborn birth weight, body mass index, head circumference and body length. Methods: Sixty-five newborns born to mothers with gestational hypertension were divided into three groups according to the diagnostic criteria of gestational hypertension in the 7th obstetrics and gynecology department: gestational hypertension group (HDP 1), 24 cases, preeclampsia 23 cases of HDP 2, 18 cases of severe preeclampsia (HDP 3) and 41 cases of normal control group. Radioimmunoassay (RIA) was used to determine umbilical blood orexin levels and the correlation between orexin levels and newborn birth weight, Birth Mass Index BMI, head circumference and body length. Results: ① The level of umbilical blood orexin in neonates with gestational hypertension was higher than that of normal control group, and the level of uterotonic umbilical blood increased progressively with the increase of hypertensive disorders in pregnancy. There was significant difference between the two groups (F = 3.962 , P <0.05). (2) The birth weight and body mass index of newborns in gestational hypertension group were lower than those in normal control group, and decreased with the increase of hypertensive disorder during pregnancy. There was significant difference between the two groups (F = 6.141, (F = 5.483, P <0.01; F = 6.352, P <0.01). The results showed that there was a significant difference between the severe preeclampsia group (P <0.01; F = 2.678, Pediatric circumference, length was significantly lower than the normal control group. (3) The level of umbilical blood orexin in neonates with gestational hypertension was negatively correlated with birth weight, body mass index, head circumference and length (r = -0.342, P <0.05; r = -0.317, P < r = -0.334, P <0.05; r = -0.287, P <0.05). CONCLUSION: Obey factors are present in umbilical blood of newborn infants with gestational hypertension and the levels of orexin are increased with the severity of hypertensive disorder during pregnancy. Orexpression is significantly associated with fetal growth and development.