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目的探讨人乳腺癌易感基因1(BRCA1)基因多态性与宫颈癌发生的关系。方法采用病例对照研究,运用多聚酶链式反应—限制性片段长度多态性(PCR-RFLP)法检测71例宫颈癌患者和68例健康人BRCA1 871 C>T单核苷酸多态性,比较上述各组基因型和等位基因频率分布有无差异。结果 BRCA1 871T/T,C/T,C/T+T/T基因型相对于C/C基因型显著降低了宫颈癌发生的风险(C/T:OR(95%CI)=0.29(0.13-0.68),T/T:OR(95%CI)=0.29(0.12-0.69),C/T+T/T:OR(95%CI)=0.29(0.14-0.61);结论 BRCA1基因突变与宫颈癌密切相关,BRCA1 871C>T降低了宫颈癌发生的风险。
Objective To investigate the relationship between human breast cancer susceptibility gene 1 (BRCA1) gene polymorphism and the occurrence of cervical cancer. Methods A case-control study was conducted to detect BRCA1 871 C> T single nucleotide polymorphisms in 71 patients with cervical cancer and 68 healthy people by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) The above groups of genotypes and allele frequency distribution with or without differences. Results Compared with C / C genotypes, BRCA1 871T / T, C / T and C / T + T / T genotypes significantly reduced the risk of cervical cancer (C / T: OR (95% CI) = 0.29 0.68), T / T: OR (95% CI) = 0.29 (0.12-0.69), C / T + T / T Closely related, BRCA1 871C> T reduces the risk of cervical cancer.