早在1924年 Policar 报告,在实验性鼠肉瘤中有内源性卟啉类物质,用光激发了见红色荧光。1942年 Anler 给小鼠静注血卟啉,发现原发肿瘤及转移肿瘤、转移淋巴结均可吸收血卟啉。1968年 Gregorie 及其同事观察了226例肿瘤,发现76%恶性肿瘤有荧光,而良性瘤仅23%有微弱荧光。这些研究 As early as 1924, Policar reported that endogenous porphyrins were present in experimental murine sarcomas and that they stimulated red fluorescence. In 1942, Anler injected hematoporphyrin into mice and found that primary tumors, metastatic tumors, and metastatic lymph nodes can absorb hematoporphyrins. In 1968 Gregorie and colleagues observed 226 tumors and found that 76% of malignant tumors had fluorescence, whereas only 23% of benign tumors had weak fluorescence. These studies