本文通过血清抗毒素水平的测定,评价了在医院内白喉暴发时,成人接种含1LfU白喉类毒素和10LfU破伤风类毒素的制剂的作用。用HeLa细胞中和法测定可能接触白喉的211名成人的血清白喉抗毒素滴度,86人低于0.01U/ml。对其中72人接种上述剂量的制剂。1个月后随访血清抗毒素水平及观察副反应。接种后抗毒素滴度从低于0.01u/ml升至0.01U/ml或以上者为血清阳转。接种4～7周后,19人白喉抗毒素仍低于0.01u/ml,其中9人接种第2剂。67人接 In this paper, we evaluated the effect of adult vaccination with 1LfU of diphtheria toxoid and 10LfU of tetanus toxoid on diphtheria outbreaks in hospitals as measured by serum antitoxin levels. Serum diphtheria antitoxin titers were determined in 211 adults who were likely to contact diphtheria with HeLa cell neutralization method, 86 below 0.01 U / ml. Of these, 72 were inoculated with the above dosage formulation. One month later, serum anti-toxin levels and side effects were observed. After inoculation antitoxin titers from less than 0.01u / ml increased to 0.01U / ml or more positive seroconversion. Nine to seven weeks after inoculation, diphtheria anti-toxin 19 was still less than 0.01u / ml, of which nine were inoculated with the second dose. 67 people pick up