以家兔自身低氧血灌注其低位脑干引起呼吸抑制为实验模型,探讨临床上常用的6种呼吸兴奋剂以及吗啡、安定等药物对呼吸中枢低氧反应的影响。结果表明:尼可刹米、美解眠、氨茶碱、吗乙苯吡酮、洛贝林和阿米屈仑除了提高通气量外,都还能明显提高呼吸中枢低氧耐受力,但两者之间无平行关系。吗乙苯吡酮和阿米屈仑还能使动脉血中P_o_2增高,P_(?o)_2降低。吗啡和安定可显著降低呼吸中枢低氧耐受力。 Rabbit hypoxemic blood perfusion of its lower brain stem caused by respiratory depression experimental model to explore the clinical commonly used six kinds of respiratory stimulants and morphine, diazepam and other drugs on the respiratory center hypoxia response. The results showed that nichemicide, mesalamine, aminophylline, eprinomectin, lobeline and amikacin not only increased ventilation, but also significantly increased the tolerance of respiratory center hypoxia, but There is no parallel relationship between the two. Ethamben and Amirangram also make arterial P_o_2 increased P_ (o) _2 decreased. Morphine and diazepam significantly reduced respiratory hypoxia tolerance.