心源性猝死是严重威胁人类健康的一种疾病,而大部分心源性猝死都是恶性心律失常引起的.在临床上寻找一种简单的、有效的方法去预测恶性心律失常是必要的.在过去20年间研究人员陆续发现了一些心室复极化指标,并实际应用于临床预测恶性心律失常,如T波顶点至终点间期、T波顶点至终点间期离散度、T波顶点至终点间期与QT比值等,这些指标都可在12导联心电图上获得.在这里,还要讨论这些复极化指标在临床相关疾病(如急性心肌梗死、心力衰竭、高血压病、早期复极综合征、Brugada综合征)中预测恶性心律失常的作用.“,”Sudden cardiac death is a serious threat to human health.Most sudden cardiac deaths are caused by malignant arrhythmia. It is necessary to find a simple and effective method to predict malignant arrhythmia in the clinic .In the last two decades,some ventricular repolarization markers(Tpeak-Tend,Tpeak-Tend dispersion and Tpeak-Tend/QT)have been found to be useful to predict malignant cardiac arrhythmias in several clinical conditions.These markers are obtained from 12 lead surface electrocardiogram.In this review,we discuss how these markers have demonstrated to be effective to predict malignant arrhythmias in medical conditions such as acute myocardial ischemia , heart failure,hypertension,early repolarization syndrome ,and Brugada syndrome.