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晚近,在继续寻找植物来源的抗癌药物时,发现瑞香科(Thymelaeaceae)荛花属(Wikst-roemia)、瑞香属(Daphne)等属的一些植物具有生理活性。除在瑞香属、Gnidia属和Lasiosi-phon属分离到瑞香毒素(Daphnetoxin)类的抗癌活性物质外,从荛花属和瑞香属多种植物中分离到木脂体(Lignan)类的活性成分。鉴于该科多种植物是我国民间常用的植物药,特别是了哥王(W.indica)早已在临床广泛地用于治疗肿瘤。本文就对这种木脂体的分布、提取分离、化学结构和生理活性等作一简述。分布自1974年Dhar等发现了哥王(W.
More recently, while continuing to search for plant-derived anti-cancer drugs, some plants belonging to the genus Wikt-roemia, Daphne, etc., of the family Thymelaeaceae, have been found to have physiological activity. In addition to the anti-cancer active substances isolated from the genus Daphnetoxin in the genus Rumeira, Gnidia and Lasiosi-phon, the active compounds of the Lignan class . In view of the multi-species plant is commonly used in China’s folk medicine, in particular, Columbia (W.indica) has long been widely used in clinical treatment of cancer. In this paper, the distribution of lignans, extraction and separation, chemical structure and physiological activity were briefly reviewed. Distribution Since 1974, Dhar found Columbia (W.