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目的检测老年支气管镜检患者镇静时单次静脉推注咪唑安定达到入睡水平的ED50,指导药物的临床用量。方法将60岁以上的老年支气管镜检患者查列入干预对象,随机分为五组,检查前按0.04、0.06、0.08、0.10、0.12mg/kg的剂量给予咪唑安定静脉推注,以入睡、呼唤无迅速应答为标准,probit法计算患者静脉推注咪唑安定的ED50。结果共完成了76例的干预观察,probit法计算的患者入睡标准静脉推注咪唑安定ED50为0.063mg/kg,95%可信区间为0.031～0.091mg/kg。结论老年肺病患者支气管镜检查镇静时静脉推注咪唑安定达到入睡水平的ED50是偏低的,临床应用中应予关注。
Objective To detect the ED50 of intravenous midazolam in sedation of elderly patients with bronchoscopy sedating, and to guide the clinical use of drugs. Methods The elderly patients over 60 years of age bronchoscopy were included in the intervention group were randomly divided into five groups, before the test 0.04,0.06,0.08,0.10,0.12 mg / kg dose of intravenous midazolam bolus to sleep, Call no rapid response as the standard, the probit method to calculate the patient intravenous infusion of midazolam ED50. RESULTS: A total of 76 interventions were completed. The patients treated with the probit method fell asleep on the standard intravenous infusion of midazolam ED50 at 0.063 mg / kg and the 95% confidence interval was 0.031 to 0.091 mg / kg. Conclusions The ED50 of intravenous bolus midazolam to fall asleep level in bronchoscopy of senile patients with lung disease is low, and should be paid attention in clinical application.