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本文通过动物实验,观察了“热毒清”注射液对以大肠杆菌内毒素在家兔体内所制作的 DIC 动物模型病理生理过程的影响。血液学和形态学的结果表明,本制剂对内毒素的 DIC 生物效应具有拮抗作用。文中并就其拮抗机制作了初步探讨。根据体外抗内毒素实验、对枯否氏细胞形态的电镜观察以及其他作者的研究工作,推测可能是通过直接降解内毒素,增强单核—吞噬细胞系统的吞噬功能以及提高 C_8旁路活性而发挥作用的。
This article through animal experiments, observed “ hot poison clear ”injection of E. coli endotoxin in rabbits in the animal model of DIC pathophysiological process. The results of hematology and morphology indicate that the preparation has antagonistic effects on the biological effects of endotoxin on DIC. The article also made a preliminary discussion on its antagonism mechanism. Based on in vitro anti-endotoxin tests, electron microscopic observation of Kupffer cell morphology, and other authors’ research work, it was speculated that it may be exerted by directly degrading endotoxin, enhancing the phagocytic function of the mononuclear phagocyte system, and increasing the C_8 by-pass activity. Role.