论文部分内容阅读
目的探讨慢性肺源性心脏病患者血浆N-端脑利钠钛前体(ET-proBNP)和心钠素(ANP)的水平及临床意义。方法对46例肺源性心脏病患者及42例正常受试者采用快速化学发光法测定血浆ET-proBNP、ANP,并行同步动脉血气分析、肺功能检查,同时应用超声波检测收缩期三尖瓣返流压力价差(TRPG)估测肺动脉压(PAP)。结果慢性肺源性心脏病患者NT-proBNP、ANP均显著高于对照组(P<0.01),且血浆NT-proBNP水平与ANP、PAP呈正相关,与PaO2、FEV1、MMEF呈负相关(均P<0.05)。结论血浆NT-proBNP和ANP共同参与了肺源性心脏病的病理生理过程,测定NT-proBNP和ANP水平的变化有助于判断肺源性心脏病病情、严重程度和估计预后。
Objective To investigate the plasma levels of N-terminal brain natriuretic peptide (ET-proBNP) and atrial natriuretic peptide (ANP) in patients with chronic cor pulmonale and its clinical significance. Methods Forty-six patients with pulmonary heart disease and 42 normal subjects were tested for fasting plasma chemiluminescence (ET-proBNP), ANP, concurrent arterial blood gas analysis and pulmonary function test. At the same time, the systolic tricuspid valve Flow pressure spread (TRPG) estimates pulmonary artery pressure (PAP). Results The NT-proBNP and ANP in patients with chronic cor pulmonale were significantly higher than those in the control group (P <0.01). The plasma levels of NT-proBNP were positively correlated with ANP and PAP and negatively correlated with PaO2, FEV1 and MMEF <0.05). Conclusion Plasma NT-proBNP and ANP are involved in the pathophysiological process of pulmonary heart disease. Determining the changes of NT-proBNP and ANP levels may be helpful in judging the severity, severity and prognosis of patients with pulmonary heart disease.